Reproducible lung protective effects of a TGFβR1/ALK5 inhibitor in the bleomycin-induced and spirometry-confirmed mouse model of IPF
RNA-seq (gene expression) · mouse · 75 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 75 samples: 7 conditions, mostly with about 12 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Reproducible lung protective effects of a TGFβR1/ALK5 inhibitor in a bleomycin-induced and spirometry-confirmed model of IPF in male micePhysiological reports · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268757_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1118689 and SRA study SRP510993. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 75 samples.
How we read this: 7 replicated groups read from 75 sample titles; they account for 75 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8298482 Lung, Saline, Rep 1 Lung, Saline,
- GSM8298483 Lung, Bleomycin day 7, Rep 1 Lung, Bleomycin day 7,
- GSM8298484 Lung, Bleomycin day 14, Rep 1 Lung, Bleomycin day 14,
- GSM8298485 Lung, Bleomycin day 21, Rep 1 Lung, Bleomycin day 21,
- GSM8298486 Lung, Bleomycin day 28, Rep 1 Lung, Bleomycin day 28,
- GSM8298487 Lung, Bleomycin day 35, Rep 1 Lung, Bleomycin day 35,
- GSM8298488 Lung, Bleomycin day 42, Rep 1 Lung, Bleomycin day 42,
- GSM8298489 Lung, Saline, Rep 2 Lung, Saline,
- GSM8298490 Lung, Bleomycin day 7, Rep 2 Lung, Bleomycin day 7,
- GSM8298491 Lung, Bleomycin day 14, Rep 2 Lung, Bleomycin day 14,
- GSM8298492 Lung, Bleomycin day 21, Rep 2 Lung, Bleomycin day 21,
- GSM8298493 Lung, Bleomycin day 28, Rep 2 Lung, Bleomycin day 28,
- GSM8298494 Lung, Bleomycin day 35, Rep 2 Lung, Bleomycin day 35,
- GSM8298495 Lung, Bleomycin day 42, Rep 2 Lung, Bleomycin day 42,
- GSM8298496 Lung, Saline, Rep 3 Lung, Saline,
- GSM8298497 Lung, Bleomycin day 7, Rep 3 Lung, Bleomycin day 7,
- GSM8298498 Lung, Bleomycin day 14, Rep 3 Lung, Bleomycin day 14,
- GSM8298499 Lung, Bleomycin day 21, Rep 3 Lung, Bleomycin day 21,
- GSM8298500 Lung, Bleomycin day 28, Rep 3 Lung, Bleomycin day 28,
- GSM8298501 Lung, Bleomycin day 35, Rep 3 Lung, Bleomycin day 35,
- GSM8298502 Lung, Bleomycin day 42, Rep 3 Lung, Bleomycin day 42,
- GSM8298503 Lung, Saline, Rep 4 Lung, Saline,
- GSM8298504 Lung, Bleomycin day 7, Rep 4 Lung, Bleomycin day 7,
- GSM8298505 Lung, Bleomycin day 14, Rep 4 Lung, Bleomycin day 14,
- GSM8298506 Lung, Bleomycin day 21, Rep 4 Lung, Bleomycin day 21,
- GSM8298507 Lung, Bleomycin day 28, Rep 4 Lung, Bleomycin day 28,
- GSM8298508 Lung, Bleomycin day 35, Rep 4 Lung, Bleomycin day 35,
- GSM8298509 Lung, Bleomycin day 42, Rep 4 Lung, Bleomycin day 42,
- GSM8298510 Lung, Saline, Rep 5 Lung, Saline,
- GSM8298511 Lung, Bleomycin day 7, Rep 5 Lung, Bleomycin day 7,
- GSM8298512 Lung, Bleomycin day 14, Rep 5 Lung, Bleomycin day 14,
- GSM8298513 Lung, Bleomycin day 21, Rep 5 Lung, Bleomycin day 21,
- GSM8298514 Lung, Bleomycin day 28, Rep 5 Lung, Bleomycin day 28,
- GSM8298515 Lung, Bleomycin day 35, Rep 5 Lung, Bleomycin day 35,
- GSM8298516 Lung, Bleomycin day 42, Rep 5 Lung, Bleomycin day 42,
- GSM8298517 Lung, Saline, Rep 6 Lung, Saline,
- GSM8298518 Lung, Bleomycin day 7, Rep 6 Lung, Bleomycin day 7,
- GSM8298519 Lung, Bleomycin day 14, Rep 6 Lung, Bleomycin day 14,
- GSM8298520 Lung, Bleomycin day 21, Rep 6 Lung, Bleomycin day 21,
- GSM8298521 Lung, Bleomycin day 28, Rep 6 Lung, Bleomycin day 28,
+ 35 more — browse all 75 samples with per-sample file links →
- GSE309471 Single-cell RNA sequencing of lung cells from bleomycin-induced and doxycycline-inducible TGF-β transgenic mouse models of pulmonary fibrosis 46 samples shares tgf, bleomycin-induced
- GSE249554 The neuroprotective effect of TGF-β1 on mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis 12 samples shares tgf, protective
- GSE308578 Consistent lack of efficacy of nintedanib in a spirometry-confirmed and bleomycin-induced mouse model of idiopathic pulmonary fibrosis 43 samples shares spirometry-confirmed, bleomycin-induced
- GSE75111 Single-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [TGFB1_IL6-48h-IL-17A/GFP+] 151 samples shares tgf
- GSE75110 Single-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [TGFB1_IL6-48h] 130 samples shares tgf
- GSE270744 Single Cell Analysis Reveals The Essential Role of TGFbeta Pathway in Shaping Immune-suppressive Microenvironment and Promoting CRPC Development 48 samples shares tgf
- GSE270743 Single Cell Analysis Reveals The Essential Role of TGFbeta Pathway in Shaping Immune-suppressive Microenvironment and Promoting CRPC Development (bulk RNA-Seq) 48 samples shares tgf
- GSE306627 TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in colorectal cancer 42 samples shares tgf
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.