GEO series
Next-generation sequencing to define the impact of Cxcl1 on murine MSC transcriptome and BM-PCa tumor microenvironment
GSE268815
Mus musculus
Expression profiling by high throughput sequencing
24 samples
2025/08/13
GPL19057
Summary
Purpose: Prostate cancer most frequently metastasizes to bone and is incurable. Metastatic prostate cancer cells thrive in bone through molecular regulation of surrounding bone stroma, including upregulation of CXCL8 (CXCL1 in mice) in MSCs. This study characterizes the changes in the bone marrow mesenchymal stem cells (MSCs) upon targeted deletion of Cxcl1 in murine MSC. It also characterized the changes in the tumor/stromal cells of tumors with Cxcl1 KO MSCs or control MSCs. These studies seek to determine the importance of MSC-derived CXCL1 in bone-metastatic prostate cancer.
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Paper (PMID 40298918) ↗
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