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Genes associated with mitogen-activated protein kinase activity in pancreatic cancer cells

GSE268817 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/05 Platform GPL24676
Summary
We performed a transcriptome analysis to determine what genes were altered in expression when U0126, MAP2K inhibitor, was administered to cells of human pancreatic cancer cell lines. Five genes including ETV5, ETV4, COL13A1, HIST1H4L/H4C13, and WDR62 were found to be particularly downregulated by the inhibition of MAPK pathway, meaning that these genes were preferentially upregulated by the active MAPK. The expression of ETV5 was most modulated, suggesting that ETV5 is strongly associated with the MAPK activity and may play a role in human pancreatic cancer.
Published in
Transcriptional regulation of ETV5 by mitogen-activated protein kinase via ETS-1 in human pancreatic cancer cells
Noguchi A, Kimura M, Saiki Y et al. · Scientific reports 2025 · PMID 40204967 · doi:10.1038/s41598-025-97166-1
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Also filed as BioProject PRJNA1118788 and SRA study SRP511080. Searching any of these in the dataset finder brings you back here.

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