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Long non-coding RNA CARDINAL regulates vascular smooth muscle cell phenotype alteration

GSE268859 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/20 Platform GPL23227
Summary
The phenotype alteration of vascular smooth muscle cells (VSMCs) is critical for vascular physiology and pathology. Transcription factors (TFs) and long non-coding RNAs (lncRNAs) play pivotal roles in the gene regulatory network underlying various biological processes, including the pathogenesis of vascular diseases. Despite the established role of MYOCD as a master TF in VSMC biology, the MYOCD-mediated lncRNA-protein regulatory network in VSMC phenotype alteration remains elusive. In this study, we conducted an unbiased screening to identify key lncRNA regulators in this regulatory network using expression correlation analysis in diseased human arteries. As a result, we identified CARDINAL, a VSMC-enriched lncRNA located upstream of MYOCD, exhibiting a strong positive expression correlation with MYOCD. Decreased CARDINAL expression was observed in atherosclerosis in both human and mouse models. The aim of this study was to investigate the impact of loss of CARDINAL in human VSMCs.
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Direct links to NCBI, no account and no request form: the whole study as GSE268859_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1119200 and SRA study SRP511227. Searching any of these in the dataset finder brings you back here.

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