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Interaction of solute carrier family 39 member 1 and dynamin related protein 1 to facilitate development of hepatocellular carcinoma by impairing mitochondrial quality control

GSE268875 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/06/10 Platform GPL24676
Summary
In this study, HCC samples from 12 non-relapsed and 15 relapsed HCC patients after surgically resection, were collected for RNA sequencing. Liver-specific SLC39A1 knockout mice (SLC39A1lko) were generated by crossing Alb-Cre mice and SLC39A1flox/flox mice. Liver samples from mice were analyzed for inflammation, fibrosis and proliferation. Mitochondrial dynamics, autophagy, ROS and mitochondrial membrane potential (MMP), were detected. Co-immunoprecipitation and molecular docking were used to identify protein interactions. Targeting 1-28 peptide of SLC39A1 was designed.
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Direct links to NCBI, no account and no request form: the whole study as GSE268875_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1119230 and SRA study SRP511254. Searching any of these in the dataset finder brings you back here.

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