GEO series
Mesenchymal stem cell-loaded hydrogel improves surgical treatment for chronic cerebral ischemia
GSE269005
Rattus norvegicus; Homo sapiens
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
18 samples
2024/06/10
GPL24676GPL32190GPL25947
Summary
Chronic cerebral ischemia (CCI) results in a prolonged insufficient blood supply to the brain tissue, leading to impaired neuronal function and subsequent impairment of cognitive and motor abilities. Our previous research showed that in mice with bilateral carotid artery stenosis, the collateral neovascularization post Encephalo-myo-synangiosis (EMS) treatment could be facilitated by bone marrow mesenchymal stem cells (MSCs) transplantation. Considering the advantages of biomaterials, we synthesized and modified a gelatin hydrogel for MSCs encapsulation. We then applied this hydrogel on the brain surface during EMS operation in rats with CCI, and evaluated its impact on cognitive performance and collateral circulation.
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