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scRNA-Seq reveals anti-fibrotic mechanisms of TRPC6 inhibition [scRNA-seq]

GSE269062 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/08 Platform GPL24247
Summary
Inhibition of transient receptor potential canonical 6 channels (TRPC6) alleviates tubular injury and renal fibrosis induced by unilateral ureteral obstruction (UUO).However, the exact renoprotective mechanisms are unknown. In this study, we utilized single-cell RNA sequencing (scRNA-Seq) to define the cellular and transcriptional landscape associated with renoprotection through in vivo TRPC6 inhibition, specifically using SH045 (larixyl N-methylcarbamate), in the UUO model.
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Also filed as BioProject PRJNA1120044 and SRA study SRP511738. Searching any of these in the dataset finder brings you back here.

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