Inhibition of CDK8/CDK19 with the small molecule inhibitor SEL120-34A in prostate cancer cell lines (3’ tag DGE)
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 3 × LNCaP, DMSO, vs 3 × LNCaP, CDKinh, vs 3 × 22Rv1, DMSO, vs 3 × 22Rv1, CDKinh,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- MED12 and CDK8/19 Modulate Androgen Receptor Activity and Enzalutamide Response in Prostate CancerEndocrinology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269071_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1120051 and SRA study SRP511785. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8305850 LNCaP, DMSO, rep1 LNCaP, DMSO,
- GSM8305851 LNCaP, DMSO, rep2 LNCaP, DMSO,
- GSM8305852 LNCaP, DMSO, rep3 LNCaP, DMSO,
- GSM8305853 LNCaP, CDKinh, rep1 LNCaP, CDKinh,
- GSM8305854 LNCaP, CDKinh, rep2 LNCaP, CDKinh,
- GSM8305855 LNCaP, CDKinh, rep3 LNCaP, CDKinh,
- GSM8305856 22Rv1, DMSO, rep1 22Rv1, DMSO,
- GSM8305857 22Rv1, DMSO, rep2 22Rv1, DMSO,
- GSM8305858 22Rv1, DMSO, rep3 22Rv1, DMSO,
- GSM8305859 22Rv1, CDKinh, rep1 22Rv1, CDKinh,
- GSM8305860 22Rv1, CDKinh, rep2 22Rv1, CDKinh,
- GSM8305861 22Rv1, CDKinh, rep3 22Rv1, CDKinh,
- GSM8305862 PC3, DMSO, rep1
- GSM8305863 PC3, CDKinh, rep1
- GSE77987 Selective CDK8 inhibitor SEL120-34A alters expression of interferon-related DNA damage resistance signature genes in colorectal cancer 24 samples shares sel120-34a, cdk8, inhibitor
- GSE240369 Effects of CDK8/19 Mediator Kinase inhibition on gene expression in castration-resistant prostate cancer cell line 22Rv1 and its derivatives grown in vitro. 48 samples shares cdk8, inhibition, prostate
- GSE303026 CDK8/19 inhibition suppresses adaptive resistance to CDK4/6 inhibitors in vitro and in vivo 44 samples shares cdk8, inhibition, inhibitor
- GSE304126 CDK8 inhibition sequesters Med1 at EWS-FLI enhancers [RNA-Seq] 68 samples shares cdk8, inhibition
- GSE271325 Transcriptomic analysis of the effects of mTOR inhibitor everolimus, CDK8/19 inhibitor SNX631 and their combination in MDA-MB-468 xenografts 50 samples shares cdk8, inhibitor
- GSE309005 Effect of CDK8/19 kinase inhibitor SNX 631 on OV90 parental and anoikis resistant isogenic lines 31 samples shares cdk8, inhibitor
- GSE300974 CDK8 Inhibition Releases the Muscle Differentiation Blockade in Fusion-driven Alveolar Rhabdomyosarcoma [RNA-seq] 30 samples shares cdk8, inhibition
- GSE240167 Effects of CDK8/19 Mediator Kinase inhibition by Senexin B and SNX631 on androgen-regulated gene expression in LNCaP cells 28 samples shares cdk8, inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.