Alzheimer’s Disease Protective Allele of CLU Promotes Neuron Excitability, Neuron-glia Lipid Transfer and Astrocytic Lipid Droplets via neuronal CLU
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communicationmedRxiv : the preprint server for health sciences · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269153_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1120422 and SRA study SRP511977. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8307137 A1_CD07_C/C_clone 1
- GSM8307138 A2_CD07_C/C_clone 1
- GSM8307139 A3_CD07_C/C_clone 2
- GSM8307140 A4_CD07_C/C_clone 2
- GSM8307141 A5_CD07_T/T_clone 1
- GSM8307142 A6_CD07_T/T_clone 1
- GSM8307143 A7_CD07_T/T_clone 2
- GSM8307144 A8_CD07_T/T_clone 2
- GSM8307145 B1_CD05_C/C_Clone1
- GSM8307146 B2_CD05_C/C_Clone1
- GSM8307147 B3_CD05_C/C_Clone2
- GSM8307148 B4_CD05_C/C_Clone2
- GSM8307149 B5_CD05_C/C_Clone2
- GSM8307150 B6_CD05_T/T_Clone1
- GSM8307151 B7_CD05_T/T_Clone1
- GSM8307152 B8_CD05_T/T_Clone2
- GSM8307153 B9_CD05_T/T_Clone2
- GSM8307154 B10_CD05_T/T_Clone2
- GSE252237 A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease (scRNA-Seq) 7 samples shares protective, alzheimer
- GSE269054 Spatially clustered type I interferon responses at injury borderzones 37 samples shares clu
- GSE159276 G-quadruplexes are promoter elements controlling nucleosome exclusion and RNA polymerase II pausing 63 samples shares clu
- GSE298706 Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain 24 samples shares protective
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.