ZEB2 is a Master Switch Controlling the Tumor-Associated Macrophage Program
RNA-seq (gene expression) · mouse · 493 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 493 samples: 348 × BMDMs, AB vs 52 × CD45 cells, ABGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ZEB2 is a master switch controlling the tumor-associated macrophage programCancer cell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269192_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1120482 and SRA study SRP512050. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 400 samples.
How we read this: 2 replicated groups read from the first 400 of 493 sample titles; they account for 400 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8307779 BMDMs, AB12212 BMDMs, AB
- GSM8307780 BMDMs, AB12213 BMDMs, AB
- GSM8307781 BMDMs, AB12214 BMDMs, AB
- GSM8307782 BMDMs, AB12215 BMDMs, AB
- GSM8307783 BMDMs, AB12216 BMDMs, AB
- GSM8307784 BMDMs, AB12217 BMDMs, AB
- GSM8307785 BMDMs, AB12219 BMDMs, AB
- GSM8307786 BMDMs, AB12220 BMDMs, AB
- GSM8307787 BMDMs, AB12221 BMDMs, AB
- GSM8307788 BMDMs, AB12222 BMDMs, AB
- GSM8307789 BMDMs, AB12223 BMDMs, AB
- GSM8307790 BMDMs, AB12224 BMDMs, AB
- GSM8307791 BMDMs, AB12225 BMDMs, AB
- GSM8307792 BMDMs, AB12226 BMDMs, AB
- GSM8307793 BMDMs, AB12233 BMDMs, AB
- GSM8307794 BMDMs, AB12234 BMDMs, AB
- GSM8307795 BMDMs, AB12235 BMDMs, AB
- GSM8307796 BMDMs, AB9052 BMDMs, AB
- GSM8307797 BMDMs, AB9053 BMDMs, AB
- GSM8307798 BMDMs, AB9054 BMDMs, AB
- GSM8307799 BMDMs, AB9055 BMDMs, AB
- GSM8307800 BMDMs, AB9056 BMDMs, AB
- GSM8307801 BMDMs, AB9057 BMDMs, AB
- GSM8307802 BMDMs, AB9058 BMDMs, AB
- GSM8307803 BMDMs, AB9059 BMDMs, AB
- GSM8307804 BMDMs, AB9061 BMDMs, AB
- GSM8307805 BMDMs, AB9062 BMDMs, AB
- GSM8307806 BMDMs, AB9063 BMDMs, AB
- GSM8307807 BMDMs, AB9064 BMDMs, AB
- GSM8307808 BMDMs, AB9065 BMDMs, AB
- GSM8307809 BMDMs, AB9066 BMDMs, AB
- GSM8307810 BMDMs, AB9067 BMDMs, AB
- GSM8307811 BMDMs, AB9068 BMDMs, AB
- GSM8307812 BMDMs, AB9069 BMDMs, AB
- GSM8307813 BMDMs, AB9070 BMDMs, AB
- GSM8307814 BMDMs, AB9071 BMDMs, AB
- GSM8307815 BMDMs, AB9072 BMDMs, AB
- GSM8307816 BMDMs, AB9073 BMDMs, AB
- GSM8307817 BMDMs, AB9074 BMDMs, AB
- GSM8307818 BMDMs, AB9075 BMDMs, AB
+ 453 more — browse all 493 samples with per-sample file links →
- GSE269191 ZEB2 is a Master Switch Controlling the Tumor-Associated Macrophage Program [in vivo] 145 samples shares zeb2, tumor-associated, controlling, macrophage, program, master, switch
- GSE269187 ZEB2 is a Master Switch Controlling the Tumor-Associated Macrophage Program [in vitro] 17 samples shares zeb2, tumor-associated, controlling, macrophage, program, master, switch
- GSE324935 IFN-γ and TLR9 signaling reprogram tumor-associated macrophages to promote antitumor immunity in melanoma 20 samples shares tumor-associated, macrophage, program
- GSE300757 Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages 127 samples shares tumor-associated, macrophage
- GSE280003 Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific programming in the lung 81 samples shares macrophage, program
- GSE250551 Targeting inflammation with chimeric antigen receptor macrophages using a signal switch 32 samples shares macrophage, switch
- GSE237783 Complex interaction of tumor-derived factors instructs the niche specific phenotypes of tumor-associated macrophages [RNA-Seq] 28 samples shares tumor-associated, macrophage
- GSE335147 Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response 24 samples shares macrophage, program
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.