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Effect of butyrate stimulation on CD19 CAR-T cells for the treatment of Non-Hodgkin Lymphoma

GSE269341 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/10/08 Platform GPL21697
Summary
Gut microbiota plays a pivotal role in the development and function of the immune system, therefore it has been described as an important factor for the efficacy and safety of immunotherapy, including CAR-T. The mechanisms by which this occurs are not well understood. Short Chain Fatty Acids (SCFAs) are metabolites derived from the microbial fermentation that are involved in the regulation of metabolic, endocrine and immune function. In this study we analyze the transcriptomic changes that SCFA butyrate generates in CAR-T cells.
Published in
The Potential of the Gut Microbiota and Butyrate to Enhance CAR T-cell Therapy in Non-Hodgkin Lymphoma
García-Vicente R, Rodríguez-García A, Ancos-Pintado R et al. · Clinical cancer research : an official journal of the American Association for Cancer Research 2026 · PMID 41231114 · doi:10.1158/1078-0432.CCR-25-1676
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Also filed as BioProject PRJNA1121250 and SRA study SRP512420. Searching any of these in the dataset finder brings you back here.

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