RNAseq of human plasmacytoid dendritic cells in adult and elderly donors
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 6 × UY vs 6 × UeGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cellsNature immunology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269411_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1121403 and SRA study SRP512507. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8314637 UY1 UY
- GSM8314638 UY2 UY
- GSM8314639 UY4 UY
- GSM8314640 UY5 UY
- GSM8314641 UY6 UY
- GSM8314642 UY7 UY
- GSM8314643 Ue2 Ue
- GSM8314644 Ue3 Ue
- GSM8314645 Ue4 Ue
- GSM8314646 Ue5 Ue
- GSM8314647 Ue6 Ue
- GSM8314648 Ue7 Ue
- GSE279911 ATAC-seq of human plasmacytoid dendritic cells in adult and elderly donors 12 samples shares plasmacytoid, dendritic, elderly, donors, adult
- GSE215052 Transcriptional profiling by 3' digital gene expression of human HSPCs isolated from the bone marrow of fetal, adult or elderly donors 57 samples shares elderly, donors, adult
- GSE254707 Single-cell transcriptomic analysis identifies infiltrating plasmacytoid dendritic cells in psoriasis epidermis 4988 samples shares plasmacytoid, dendritic
- GSE266889 SMART-seq2 of activated human plasmacytoid dendritic cells 383 samples shares plasmacytoid, dendritic
- GSE294888 Differential response of human plasmacytoid pre-dendritic cells to SARS-CoV-2 variants 40 samples shares plasmacytoid, dendritic
- GSE273852 Age- and Tissue-dependent Diversity of Human Plasmacytoid Dendritic Cells Uncovers a Cycling Subset Dominant in Early Life and Cancer 13 samples shares plasmacytoid, dendritic
- GSE261447 Unique CD8+ T Cell Priming by Antigen Presenting Plasmacytoid Dendritic Cells Compared to Conventional Dendritic Cells 15 samples shares plasmacytoid, dendritic
- GSE278318 Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis [PDX] 28 samples shares plasmacytoid, dendritic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.