Metabolic programs drive function of therapeutic natural killer (NK) cells in low oxygen tumor microenvironments
RNA-seq (gene expression) · human · 63 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 63 samples: 61 distinct titles, 1 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Metabolic programs drive function of therapeutic NK cells in hypoxic tumor environmentsScience advances · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269629_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1122791 and SRA study SRP513289. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 63 sample titles: 61 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8323183 Group A, O2-20, 0psi, 1 day, D1, S01
- GSM8323184 Group A, O2-20, 0psi, 1 day, D2, S02
- GSM8323185 Group A, O2-20, 0psi, 1 day, D3, S03
- GSM8323186 Group A, O2-20, 0psi, 1 day, D4, S04
- GSM8323187 Group B, O2-12, 2psi, 1 day, D2, S05
- GSM8323188 Group B, O2-12, 2psi, 1 day, D3, S06
- GSM8323189 Group C, O2-05, 0-6psi, 1 day, D1, S07
- GSM8323190 Group C, O2-05, 0-6psi, 1 day, D2, S08
- GSM8323191 Group C, O2-05, 0-6psi, 1 day, D4, S09
- GSM8323192 Group D, O2-01, 0-3psi, 1 day, D1, S10
- GSM8323193 Group D, O2-01, 0-3psi, 1 day, D2, S11
- GSM8323194 Group D, O2-01, 0-3psi, 1 day, D3, S12
- GSM8323195 Group D, O2-01, 0-3psi, 1 day, D4, S13
- GSM8323196 Group E, O2-01, 2psi, 1 day, D1, S14
- GSM8323197 Group E, O2-01, 2psi, 1 day, D2, S15
- GSM8323198 Group E, O2-01, 2psi, 1 day, D3, S16
- GSM8323199 Group E, O2-01, 2psi, 1 day, D4, S17
- GSM8323200 Group F, O2-20, 0psi, 3 day, D2, S18
- GSM8323201 Group H, O2-05, 0-6psi, 3 day, D3, S19
- GSM8323202 Group I, O2-01, 0-3psi, 3 day, D1, S20
- GSM8323203 Group I, O2-01, 0-3psi, 3 day, D3, S21
- GSM8323204 Group I, O2-01, 0-3psi, 3 day, D4, S22
- GSM8323205 Group J, O2-01, 2psi, 3 day, D2, S24
- GSM8323206 Group J, O2-01, 2psi, 3 day, D3, S25
- GSM8323207 Group J, O2-01, 2psi, 3 day, D4, S26
- GSM8323208 Group K, O2-20, 0psi, 7 day, D1, S27
- GSM8323209 Group K, O2-20, 0psi, 7 day, D2, S28
- GSM8323210 Group K, O2-20, 0psi, 7 day, D4, S29
- GSM8323211 Group L, O2-12, 2psi, 7 day, D2, S30
- GSM8323212 Group L, O2-12, 2psi, 7 day, D4, S31
- GSM8323213 Group M, O2-05, 0-6psi, 7 day, D2, S32
- GSM8323214 Group M, O2-05, 0-6psi, 7 day, D2, S33
- GSM8323215 Group M, O2-05, 0-6psi, 7 day, D2, S34
- GSM8323216 Group N, O2-01, 0-3psi, 7 day, D1, S35
- GSM8323217 Group N, O2-01, 0-3psi, 7 day, D2, S36
- GSM8323218 Group N, O2-01, 0-3psi, 7 day, D3, S37
- GSM8323219 Group N, O2-01, 0-3psi, 7 day, D4, S38
- GSM8323220 Group O, O2-01, 2psi, 7 day, D1, S39
- GSM8323221 Group O, O2-01, 2psi, 7 day, D2, S40
- GSM8323222 Group O, O2-01, 2psi, 7 day, D3, S41
+ 23 more — browse all 63 samples with per-sample file links →
- GSE235738 Alveolar Soft Part Sarcoma is driven by ASPSCR1::TFE3-dependent and therapeutically targetable transcriptional programs [RNA-Seq] 35 samples shares therapeutic, programs, drive
- GSE280973 Transcriptional Regulation of Protein Synthesis by Mediator Kinase Represents a Therapeutic Vulnerability in MYC-driven Medulloblastoma 20 samples shares therapeutic, drive
- GSE316970 CYD-4-61 Suppresses Gastric Tumor Growth by Targeting SOX9–CDK4–Driven Oncogenic Programs and Enhances Anti-PD-1 Therapy 18 samples shares programs, drive
- GSE285857 Mutant KRAS-Driven Selective mRNA Translation Reveals Mechanisms and Therapeutic Vulnerabilities in Cancer 48 samples shares therapeutic, drive
- GSE274986 Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration [scMultiome] 26 samples shares programs, drive
- GSE264550 Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer 25 samples shares programs, drive
- GSE307120 Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma 21 samples shares programs, drive
- GSE292489 Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells 20 samples shares natural, killer
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.