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Patient-derived lymphomoids preserve the tumor architecture and allow testing response to therapies in lymphoma [scRNA-seq]

GSE269697 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/11/26 Platform GPL21103
Summary
We designed an ex vivo system to culture tissue explants from lymphoma tissue. To determine if the explants derived from vavP-Bcl2 mouse spleens retained the cellular composition and transcriptional profile of the cells in the original tissue, we analyzed six lymphomoids derived from the spleens of two mice, after one or two weeks in culture, and the original spleen tissues by single-cell RNA-sequencing.
Published in
Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening
Santamaria-Martínez A, Epiney J, Srivastava D et al. · Nature communications 2024 · PMID 39653701 · doi:10.1038/s41467-024-55098-w
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Direct links to NCBI, no account and no request form: the whole study as GSE269697_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1123245 and SRA study SRP513553. Searching any of these in the dataset finder brings you back here.

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