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Temporal regulation of PARP1 acetylation in tumorigenesis

GSE269944 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/10/23 Platform GPL24676
Summary
We examined the impact of PARP1-ATF4 interaction on cellular transcription program. ATF4 plays a pivotal role in stress response by regulating expression of diverse genes. Under genotoxic stress, the acetylation status of PARP1 at lysine 521 influences the expression of diverse genes. Also, co-depletion of ATF4 leads to the downregulation of many genes. These genes are involved in pathways related to cancer risk, such as epithelial-to-mesenchymal transition (EMT), metastasis, cell cycle regulation, and metabolic processes.
Published in
Temporal regulation of acetylation status determines PARP1 role in DNA damage response and metabolic homeostasis
Tyagi W, Das S · Science advances 2024 · PMID 39423262 · doi:10.1126/sciadv.ado7720
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Also filed as BioProject PRJNA1124153 and SRA study SRP514069. Searching any of these in the dataset finder brings you back here.

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