GEO series
Targeting ferroptosis resistance re-sensitizes metastatic HR+ HER2- breast cancer to palbociclib-hormone therapy
GSE270021
Homo sapiens
Expression profiling by high throughput sequencing
21 samples
2025/01/06
GPL24676
Summary
HR+HER2- breast cancers resistant to palbociclib-hormone therapy displayed increased lipid uptake and expression of stress response proteins (GPX4, PSMA7), by adding ferroptosis inducers to palbocilib-fulvestrant combination therapy, tumor response was enhanced in three different pre-clinical models: resistant cells, xenografts and PDX.
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Paper (PMID 39801257) ↗
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