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Effect of HES1 overexpression on gene expression of adipose stem cells [RNA-seq]

GSE270037 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/13 Platform GPL24676
Summary
In the current investigation, an RNA-seq analysis was conducted to examine the differentially expressed genes in old ADSCs (O-ADSCs) following the overexpression of HES1. The findings indicated that 448 genes exhibited increased levels, while 865 genes showed decreased levels in the oe-HES1 O-ADSCs compared to the oe-NC O-ADSCs. The GO analysis revealed that these genes are primarily localized in the nucleus and cytoplasm, and are involved in activities such as protein binding and DNA binding. Furthermore, they are associated with processes related to cell adhesion and the regulation of transcription by RNA polymerase II. The KEGG analysis indicated enrichment in pathways such as the NOD-like receptor signaling pathway, TNF signaling pathway, IL-17 signaling pathway, and PI3K-Akt signaling pathway.
Published in
HES1 revitalizes the functionality of aged adipose-derived stem cells by inhibiting the transcription of STAT1
Li C, Ren S, Yan C et al. · Stem cell research & therapy 2024 · PMID 39501364 · doi:10.1186/s13287-024-04002-w
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Also filed as BioProject PRJNA1124895 and SRA study SRP514333. Searching any of these in the dataset finder brings you back here.

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