The SGLT2 Inhibitor Empagliflozin Enhances Metabolic Efficiency and Ameliorates Left Ventricular Hypertrophy in Myosin R403Q Mutant Hypertrophic Cardiomyopathy Mice
RNA-seq (gene expression) · mouse · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 21 samples: 21 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse modelEuropean heart journal · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270093_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1124979 and SRA study SRP514449. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 21 sample titles: 21 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8334357 WT CD 68657NN
- GSM8334358 WT CD 68660LN
- GSM8334359 WT CD 68660RN
- GSM8334360 WT CD 68664DR
- GSM8334361 WT CD 68666LN
- GSM8334362 WT EMPA 68691LN
- GSM8334363 WT EMPA 68691NN
- GSM8334364 WT EMPA 68691RN
- GSM8334365 WT EMPA 68692LN
- GSM8334366 WT EMPA 68695RN
- GSM8334367 R403Q CD 68657RN
- GSM8334368 R403Q CD 68660NN
- GSM8334369 R403Q CD 68664BN
- GSM8334370 R403Q CD 68664RN
- GSM8334371 R403Q CD 68666BN
- GSM8334372 R403Q CD 68666NN
- GSM8334373 R403Q CD 68666RN
- GSM8334374 R403Q EMPA 68692NN
- GSM8334375 R403Q EMPA 68692RN
- GSM8334376 R403Q EMPA 68695LN
- GSM8334377 R403Q EMPA 68695NN
- GSE283722 SGLT2 Inhibitor Empagliflozin Enhances Metabolic Efficiency and Ameliorates Left Ventricular Hypertrophy in Myosin R403Q Mutant Hypertrophic Cardiomyopathy Mice 6 samples shares sglt2, r403q, cardiomyopathy, empagliflozin, hypertrophic, ameliorates, ventricular, hypertrophy
- GSE297707 Beneficial Effects of High Intensity Interval Training in a Mouse Model of Hypertrophic Cardiomyopathy 64 samples shares cardiomyopathy, hypertrophic
- GSE261796 High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice 40 samples shares cardiomyopathy, ameliorates
- GSE326721 Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [RNASeq_LSM] 16 samples shares cardiomyopathy, hypertrophic
- GSE326720 Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [RNASeq_MAVA] 13 samples shares cardiomyopathy, hypertrophic
- GSE239872 Base editing effectively prevents the early-onset hypertrophic cardiomyopathy in Mybpc3 mutant mice 9 samples shares cardiomyopathy, hypertrophic
- GSE233851 Bulk RNA-sequencing from whole heart lysates of a mouse model of hypertrophic cardiomyopathy after TTL overexpression. 9 samples shares cardiomyopathy, hypertrophic
- GSE266649 Contribution of hypoxia-inducible 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy 4 samples shares cardiomyopathy, hypertrophic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.