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Single-Cell Sequencing of IDH-Mutant Glioma

GSE270109 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/06/21 Platform GPL24676
Summary
Glioma, a prevalent and deadly brain tumor, is marked by significant cellular heterogeneity and metabolic alterations, yet the comprehensive cell-of-origin and metabolic landscape in high-grade (Glioblastoma Multiforme, WHO grade IV) and low-grade (Oligoastrocytoma, WHO grade II) gliomas remains elusive. In this study, we undertook single-cell transcriptome sequencing of these glioma grades to elucidate their cellular and metabolic distinctions. Following the identification of cell types, we compared metabolic pathway activities and gene expressions between high-grade and low-grade gliomas. The comprehensive analysis identified the most altered metabolic pathways (MCPs) and genes across all cell types, which were further validated against TCGA and CGGA datasets for their clinical significance.
Published in
Single-cell transcriptomic analysis identifies downregulated phosphodiesterase 8B as a novel oncogene in IDH-mutant glioma
He Z, Peng Y, Wang D et al. · Frontiers in immunology 2024 · PMID 38989284 · doi:10.3389/fimmu.2024.1427200
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Also filed as BioProject PRJNA1125010 and SRA study SRP514458. Searching any of these in the dataset finder brings you back here.

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