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XPO1-dependency of DEK::NUP214 leukemia sensitizes against eltanexor

GSE270396 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/03/28 Platform GPL16791
Summary
We aimed to investigate the role of XPO1 in this rare leukemia subtype. ChIP-sequencing was performed for XPO1 and NUP214 (as surrogate for DEK::NUP214 protein), and found co-occupancy of both proteins in putative DEK::NUP214 target genes.
Published in
XPO1-dependency of DEK::NUP214 leukemia
Charles Cano F, Kloos A, Hebalkar RY et al. · Leukemia 2025 · PMID 40148556 · doi:10.1038/s41375-025-02570-1
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Also filed as BioProject PRJNA1126303 and SRA study SRP515106. Searching any of these in the dataset finder brings you back here.

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