← BioTransfer GEO Dataset Finder
GEO series

Study on the mechanism of toll-like receptor junction molecule TICAM1 promoting the occurrence and development of acute myeloid leukemia

GSE270403 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/03/17 Platform GPL30209
Summary
TICAM1 is recruited into intracellular vesicles to mediate TLR3/4 signaling involved in innate immunity, however the role of this pathway in the pathogenesis of acute myeloid leukemia (AML) remains unknown. We found that in myelomonocytic (M4) and monocytic (M5) AML cells, TLR3/4 was highly expressed, and activation of TLR3/4-TICAM1 signaling was an independent indicator of poor prognosis. TLR3/4 agonists significantly promoted the proliferation of these subtypes of AML cells but inhibited the proliferation of other subtypes of AML cells. Silencing TICAM1 significantly inhibited the growth of M5 AML cells in vitro and in vivo, enhanced their chemotherapy sensitivity, and led to decreased phosphorylation of TBK1 and RIPK3. Using MLL-AF9-driven murine AML model, we investigated the molecular mechanism by which TLR3/4-TICAM1 signaling promotes AML cell growth and drug resistance in vivo and in vitro. Therefore, this study likely provides a new theoretical and experimental basis for the treatment of such disease.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE270403_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1126307 and SRA study SRP515114. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.