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Macrophage Involvement in the Pathology of Chronic Thromboembolic Pulmonary Hypertension: Lessons from Single-Cell and Single-Nucleus RNA Sequencing

GSE270483 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/01 Platform GPL24676
Summary
We revealed the detailed landscape of myeloid cells in CTEPH and identified cell-cell interactions between myeloid and non-immune cells using both scRNA-seq and snRNA-seq. The interaction between SPP1/FN1+ macrophages and FAP+ FBs or MyoFBs may be a therapeutic target in CTEPH.
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Also filed as BioProject PRJNA1126726 and SRA study SRP515352. Searching any of these in the dataset finder brings you back here.

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