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Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis

GSE270517 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2025/06/27 Platform GPL24676
Summary
Cardiac fibrosis is the hallmark underlying variosus forms of heart disease including aortic stenosis, contributing significantly to disease progression and mortality. However, the molecular mechanistic details remain largely unknown. We conducted single nucleus RNA sequencing (snRNA-seq) on human fibrotic AS and non-failing donor heart samples to track pathological changes at single-cell resolution and to identify cell-specific candidate genes involved in cardiac fibrosis.
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Direct links to NCBI, no account and no request form: the whole study as GSE270517_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1127309 and SRA study SRP515504. Searching any of these in the dataset finder brings you back here.

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