← BioTransfer GEO Dataset Finder
GEO series

Characterization of gene profile between ALDH high LNCaP cells and ALDH low LNCaP cells

GSE270565 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/15 Platform GPL34281
Summary
Acquisition of prostate cancer stem cells (PCSCs) manifested during androgen ablation therapy (ABT) contributes to castration-resistant prostate cancer (CRPC). However, little is known about the specific metabolites critically orchestrating this process. Here, we show t+B13hat IMPA1-derived inositol enriched in PCSCs is a key metabolite crucially maintaining PCSCs for CRPC progression and ABT resistance.
Published in
IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation
Hsu CC, Wang G, Li CF et al. · The Journal of experimental medicine 2024 · PMID 39470689 · doi:10.1084/jem.20231832
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE270565_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1127501 and SRA study SRP516151. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.