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Genome-wide profiling of TFEB targets in melanoma

GSE270585 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/09/03 Platform GPL20301
Summary
Unlike MITF-M, the melanocyte-specific isoform of MITF, TFEB, TFE3 and non-melanocyte MITF isoforms are regulated primarily by mTORC1-mediated phosphorylation at the lysosome that promotes their cytoplasmic retention. As low levels of glucose or amino acids trigger down-regulation of MITF, it is likely that on nutrient limitation some MITF functions are assumed by TFE3 and TFEB, enabling MITFLow melanoma cells to survive and proliferate. The role TFEB and TFE3 in melanoma biology and their impact on MITF-driven proliferation is poorly understood.
Published in
MITF, TFEB, and TFE3 drive distinct adaptive gene expression programs and immune infiltration in melanoma
Dias D, Oliveira E, Martí-Díaz R et al. · Cell reports 2025 · PMID 41275493 · doi:10.1016/j.celrep.2025.116499
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Also filed as BioProject PRJNA1127526 and SRA study SRP515815. Searching any of these in the dataset finder brings you back here.

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