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Dietary 3-Aminobenzoic Acid Enhances Intestinal Barrier Integrity and Attenuates Experimental Colitis

GSE270624 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/01 Platform GPL34281
Summary
Dietary components and their metabolites produced by intestinal bacteria play a crucial role in maintaining intestinal epithelial integrity. Disrupted epithelial integrity can lead to increased permeability and chronic inflammation in the colon, known as ulcerative colitis (UC), in genetically predisposed individuals. Our data identified 3-aminobenzoic acid (3-ABA) as a key metabolite that reduces epithelial permeability and enhances barrier integrity in Caco2 cells by modulating the tight junctional regulatory pathway. Attenuated experimental colitis in mice treated with 3-ABA and decreased fecal 3-ABA in patients with UC implied the potential usefulness of 3-ABA as a novel treatment target for UC.
Published in
Dietary 3-aminobenzoic acid enhances intestinal barrier integrity and attenuates experimental colitis
Tanaka M, Toyonaga T, Nakagawa F et al. · American journal of physiology. Gastrointestinal and liver physiology 2025 · PMID 40338094 · doi:10.1152/ajpgi.00406.2024
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Also filed as BioProject PRJNA1127585 and SRA study SRP516136. Searching any of these in the dataset finder brings you back here.

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