An HSF1-JMJD6-HSP feedback circuit promotes cell adaptation to proteotoxic stress [RNA-Seq]
RNA-seq (gene expression) · human · 17 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 17 samples: 3 × MA_PC3M_siNT vs 3 × MA_PC3M_siNT_HS vs 3 × MA_PC3M_siJMJD6_HSGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- An HSF1-JMJD6-HSP feedback circuit promotes cell adaptation to proteotoxic stressProceedings of the National Academy of Sciences of the United States of America · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270672_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1127665 and SRA study SRP515692. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 9 samples.
How we read this: 3 replicated groups read from 17 sample titles; they account for 9 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8349795 MA_PC3M_X1_NT_DMSO
- GSM8349796 MA_PC3M_X2_NT_DMSO
- GSM8349797 MA_PC3M_X1_NT_MG132
- GSM8349798 MA_PC3M_X2_NT_MG132
- GSM8349799 MA_PC3M_X1_siJMJD6_MG132
- GSM8349800 MA_PC3M_X2_siJMJD6_MG132
- GSM8349801 MA_PC3M_dH1A_MG132
- GSM8349802 MA_PC3M_dH1B_MG132
- GSM8349803 MA_PC3M_siNT_1 MA_PC3M_siNT
- GSM8349804 MA_PC3M_siNT_2 MA_PC3M_siNT
- GSM8349805 MA_PC3M_siNT_3 MA_PC3M_siNT
- GSM8349806 MA_PC3M_siNT_HS_1 MA_PC3M_siNT_HS
- GSM8349807 MA_PC3M_siNT_HS_2 MA_PC3M_siNT_HS
- GSM8349808 MA_PC3M_siNT_HS_3 MA_PC3M_siNT_HS
- GSM8349809 MA_PC3M_siJMJD6_HS_1 MA_PC3M_siJMJD6_HS
- GSM8349810 MA_PC3M_siJMJD6_HS_2 MA_PC3M_siJMJD6_HS
- GSM8349811 MA_PC3M_siJMJD6_HS_3 MA_PC3M_siJMJD6_HS
- GSE270671 An HSF1-JMJD6-HSP feedback circuit promotes cell adaptation to proteotoxic stress [ChIP-Seq] 16 samples shares hsf1-jmjd6-hsp, proteotoxic, adaptation, feedback, promotes, circuit, stress
- GSE314771 Positive Feedback Regulation of Glycolysis by H4K5 Lactylation Promotes Malignant Progression of Hepatocellular Carcinoma [RNA-seq] 12 samples shares feedback, promotes, rna-seq
- GSE311827 AP-1 Mediates Cellular Adaptation and Memory Formation [Bulk RNA-seq] 192 samples shares adaptation, rna-seq
- GSE234181 Long-term multi-modal recording reveals epigenetic adaptation routes in dormant breast cancer cells [scRNA-Seq] 184 samples shares adaptation, rna-seq
- GSE234171 Long-term multi-modal recording reveals epigenetic adaptation routes in dormant breast cancer cells [RNA-Seq] 51 samples shares adaptation, rna-seq
- GSE316692 Gene syntax defines supercoiling-mediated transcriptional feedback [RNA-seq] 24 samples shares feedback, rna-seq
- GSE271456 Locus-specific and genome-wide analysis of adaptations to hypoxia in iPSC-derived endothelium from a population adapted to high altitude [RNA-Seq] 20 samples shares adaptation, rna-seq
- GSE247690 Cellular adaptation to cancer therapy along a resistance continuum [scRNA-seq: PDX] 17 samples shares adaptation, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.