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Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing [dCas9-DNMT3A ChIP-seq]

GSE270885 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/06/02 Platform GPL28038
Summary
To investigate the genome-wide occupancy of the DNA methylation editing tool dCas9-DNMT3A in cells harboring non-targeting sgRNAs (CTRL) and cells harboring sgRNAs targeting the IL1RN promoter (sgIL1RN).
Published in
Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing
Valcárcel G, Lazarenkov A, López-Rubio AV et al. · Science advances 2025 · PMID 40668918 · doi:10.1126/sciadv.adt1644
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Also filed as BioProject PRJNA1128694 and SRA study SRP516308. Searching any of these in the dataset finder brings you back here.

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