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RNAseq analysis of mouse tumor-infiltrating CD8 T cells WT or KO for AhR

GSE271049 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/09/30 Platform GPL24247
Summary
Cancer immuno-surveillance and response to checkpoint blockade therapy can be affected by multiple environmental factors, including nutrition. However, the direct effects of individual nutrients on anti-tumoral immune responses remain poorly understood. Here we addressed the impact of dietary ligands of Aryl Hydrocarbon receptor (AhR), a transcription factor activated by indoles and tryptophan catabolites generated through food digestion and microbiota metabolism. We show that T cells are the direct cellular targets of dietary AhR ligands. Transcriptomic analysis showed that tonic activation of AhR promotes anti-PD1-mediated reinvigoration of progenitor exhausted CD8 T cells by controlling their metabolic fitness, and licences the functional program of effector CD8 T cells.
Published in
Physiological activation of Aryl hydrocarbon receptor by food-derived ligands is essential for the efficacy of anti-PD1 therapy
De Juan A, Coillard A, Cros A et al. · Nature communications 2025 · PMID 41331250 · doi:10.1038/s41467-025-66854-x
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Also filed as BioProject PRJNA1129495 and SRA study SRP516791. Searching any of these in the dataset finder brings you back here.

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