Immediate early splicing controls de novo protein synthesis after T cell activation
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Immediate early splicing controls translation in activated T-cells and is mediated by hnRNPC2 phosphorylationThe EMBO journal · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271051_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1129497 and SRA study SRP516798. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8367782 HEK_CTRL_MO_1_1
- GSM8367783 HEK_CTRL_MO_2_1
- GSM8367784 HEK_CTRL_MO_3_1
- GSM8367785 HEK_hnRNPC_MO_1_1
- GSM8367786 HEK_hnRNPC_MO_2_1
- GSM8367787 HEK_hnRNPC_MO_3_1
- GSM8367788 HELA_CTRL_MO_1_1
- GSM8367789 HELA_CTRL_MO_2_1
- GSM8367790 HELA_CTRL_MO_3_1
- GSM8367791 HELA_hnRNPC_MO_1_1
- GSM8367792 HELA_hnRNPC_MO_2_1
- GSM8367793 HELA_hnRNPC_MO_3_1
- GSM8367794 Jsl1-NS-1_1
- GSM8367795 Jsl1-NS-2_1
- GSM8367796 Jsl1-30-1_1
- GSM8367797 Jsl1-30-2_1
- GSM8367798 Jsl1-150-1_1
- GSM8367799 Jsl1-150-2_1
- GSE289881 Exploring fibroblast activation protein as an early biomarker in chronic lung allograft dysfunction 10 samples shares activation, protein, early
- GSE254732 Inhibition of PCSK9 with evolocumab modulates lipoproteins and monocyte activation in high-risk ASCVD subjects 215 samples shares activation, protein
- GSE282668 TGF-β signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration 54 samples shares activation, protein
- GSE297994 Native long-read RNA sequencing of human monocytes reveals activation-induced alternative splicing toward functional isoforms 22 samples shares activation, splicing
- GSE100638 Large-scale tethering of RNA binding proteins discovers alternative splicing regulators 220 samples shares splicing, protein
- GSE311573 Disordered protein LAT encodes relative levels of signaling pathways in T cell activation 62 samples shares activation, protein
- GSE261897 Disruption of deoxynucleotide biosynthesis leads to RASproto-oncogene activation and perturbation of mitochondrial metabolism. 42 samples shares activation, synthesis
- GSE311572 Disordered protein LAT encodes relative levels of signaling pathways in T cell activation [Perturb-CITE-seq] 22 samples shares activation, protein
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.