Comparative transcriptomics of Nipah virus infection in human and fruit bat cells

We used bulk RNA sequencing to investigate the transcriptomic signature of fruit bat and human cells after Nipah virus infection. We have infected immortalized and bat and human cells and collected samples at 0, 8, 24, 48 hours-post-infection (hpi). Positive cells to infection were sorted at 24 and 48hpi. We also have infected primary bat and human cells and collected samples at 0 and 48hpi. We analyzed inter- and intra-species responses to highlight mecanims allowing bat to control Nipah virus infection.