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Single-nuclear RNA sequencing of human left atrial appendage

GSE271229 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/31 Platform GPL24676
Summary
We herein utilized SnRNA-Seq to analyze left atrial appendage (LAA) tissues to construct a comprehensive human transcriptional profile of AF. We identified a cardiomyocyte subpopulation with high energy metabolic activity (CM_1) and an adipocyte subpopulation with a specific metabolic regulating ability (Adip_0). We also demonstrated a specific myocardial energy metabolic remodeling in AF that promoted glycolytic metabolism and inhibited mitochondrial respiratory capacity. Our results showed that epicardial adipose tissues (EAT) played a unique role in regulating this process and that cell death-inducing DFFA-like effector A (CIDEA) in EAT triggered myocardial metabolic remodeling by promoting the paracrine effects.
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Also filed as BioProject PRJNA1127787 and SRA study SRP517040. Searching any of these in the dataset finder brings you back here.

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