GEO series
RNAseq of human primary lung adenocarcinoma and brain metastases
GSE271259
Homo sapiens
Expression profiling by high throughput sequencing
40 samples
2025/12/08
GPL24676
Summary
Non-small cell lung cancer (NSCLC) exhibits the highest rates of brain metastases (BM) among all solid tumors and presents a significant clinical challenge. The development of novel therapeutic strategies targeting BM is clearly needed. We performed RNA sequencing on primary lung adenocarcinoma (LUAD) and matched brain metastases (BM) cases. Additionally, we performed RNA sequencing on MET amplified and non-MET amplified LUAD BM to evaluate transcriptomic differences in these molecular subsets.
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Paper (PMID 41411048) ↗
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