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ZNF252P promotes tumorigenesis by activating c-Myc-mediated positive feedback loop

GSE271524 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/21 Platform GPL24676
Summary
Here we screened and identified a novel oncogenic lncRNA, ZNF252P, which is upregulated in a variety of cancer types. ZNF252P promotes cancer cell proliferation and tumorigenicity in vitro and in vivo by activating c-Myc-mediated positive feedback loop. The pivotal regulatory axis of ZNF252P/c-Myc gives it the potential to be the promising biomarker and therapeutic target in cancer development.
Published in
8q24 derived ZNF252P promotes tumorigenesis by driving phase separation to activate c-Myc mediated feedback loop
Qu T, Zhang C, Lu X et al. · Nature communications 2025 · PMID 40011431 · doi:10.1038/s41467-025-56879-7
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Also filed as BioProject PRJNA1132162 and SRA study SRP518116. Searching any of these in the dataset finder brings you back here.

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