Constitutive Epidermal Osteopontin Expression in Osteopontin-Null Mice Develop Ultraviolet B-Induced Cutaneous Squamous Cell Carcinomas Comparable to Wild-Type Mice
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Constitutive epidermal expression of osteopontin in osteopontin-null mice restores ultraviolet B-induced cutaneous squamous cell carcinomas to wild-type levelsCarcinogenesis · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271536_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1132181 and SRA study SRP518125. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8378979 K14 OPN UVB 1 K14 OPN UVB
- GSM8378980 K14 OPN UVB 2 K14 OPN UVB
- GSM8378981 K14 OPN UVB 3 K14 OPN UVB
- GSM8378982 K14 OPN noTx 2 K14 OPN noTx
- GSM8378983 K14 OPN noTx 1 K14 OPN noTx
- GSM8378984 K14 OPN noTx 11 K14 OPN noTx
- GSM8378985 OPN KO UVB 13 OPN KO UVB
- GSM8378986 OPN KO UVB 14 OPN KO UVB
- GSM8378987 OPN KO UVB 15 OPN KO UVB
- GSM8378988 OPN KO UVB 16 OPN KO UVB
- GSM8378989 OPN KO noTx 8 OPN KO noTx
- GSM8378990 OPN KO noTx 9 OPN KO noTx
- GSM8378991 OPN KO noTx 10 OPN KO noTx
- GSM8378992 WT UVB 6 WT UVB
- GSM8378993 WT UVB 7 WT UVB
- GSM8378994 WT UVB 8 WT UVB
- GSM8378995 WT noTx 10 WT noTx
- GSM8378996 WT noTx 11 WT noTx
- GSE245747 Transcriptome Analysis in Mouse Skin After Exposure to Ultraviolet Radiation from a Canopy Sunbed 145 samples shares ultraviolet
- GSE306718 Macrophage Cluster of Differentiation 163 promotes post-infarction cardiac repair and preserves left ventricular function via osteopontin 37 samples shares osteopontin
- GSE328461 Osteopontin mediates acquired resistance to hypoxia-inducing antiangiogenics and promotes anti-PD-L1 refractoriness in breast cancer models 37 samples shares osteopontin
- GSE328134 Adipose tissue inflammation mediated by CCL19 overexpression exacerbates experimental periodontitis via elevated circulating saturated fatty acids and osteopontin in Western-diet-fed mice 36 samples shares osteopontin
- GSE289016 Graded constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironment dependence [M002] 35 samples shares constitutive
- GSE289013 Graded constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironment dependence 32 samples shares constitutive
- GSE303259 SRF fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors [C2C12] 17 samples shares constitutive
- GSE314547 Estradiol disrupts constitutive androstane receptor (CAR)-mediated bile acid homeostasis in a murine model of intrahepatic cholestasis of pregnancy (ICP), and this effect is reversed by CAR ligands 16 samples shares constitutive
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.