GEO series
RNA-seq analysis of WT and STING knockout airway derived cell lines
GSE271679
Homo sapiens
Expression profiling by high throughput sequencing
34 samples
2024/07/22
GPL18573
Summary
In a screen of airway-derived cell lines, we found several that appeared to resist SARS-CoV-2 replication despite expressing the viral receptor, ACE2. We found that innate immune activation mediated by cGAS-STING and subsequent upregulation of interferons and interferon-stimulated genes underlies this phenotype. RNA-seq was conducted on WT and STING knockout (via CRISPR) SCC25, H596, OE21 and Detroit 562 and WT Calu-3 cell lines
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Paper (PMID 39333139) ↗
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