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Effect of Alpelisib treatment and PIK3CA knockout on gene expression of the EBV+ gastric cancer cell line YCCEL1

GSE271761 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/10/08 Platform GPL18573
Summary
EBV+ gastric cancer cell line was reported with PI3K pathway activated. Alpelisib is the PIK3CA specific inhibitor. To compare the drug treatment against the gene knockout, RNAseq was conducted to study the gene expression changes in YCCEL1.
Published in
The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane
Wang Y, Liao Y, Sun Y et al. · Nature communications 2025 · PMID 41315365 · doi:10.1038/s41467-025-65760-6
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Also filed as BioProject PRJNA1133048 and SRA study SRP518955. Searching any of these in the dataset finder brings you back here.

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