← BioTransfer GEO Dataset Finder
GEO series

Hemoglobin-induced Transcriptomic Changes in Human Cerebral Arteries

GSE271989 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/07/15 Platform GPL34281Platform GPL21697
Summary
Hemoglobin (Hb) in the subarachnoid space significantly impacts cerebral vessels, leading to various pathological outcomes. The toxicity of cell-free Hb released from erythrocytes and its metabolites is suggested to cause vasoconstriction and neuronal damage, correlating with delayed ischemic neurological deficits (DIND). Here, we aim to describe the changes in the genetic profile of human cerebral arteries exposed to free Hb for 48 hours. We performed an ex vivo treatment followed by mRNA sequencing of the vessels
Published in
Gene expression changes in human cerebral arteries following hemoglobin exposure: implications for vascular responses in SAH
Shafeeque CM, Harmanci AO, Thomas S et al. · Frontiers in physiology 2025 · PMID 40247928 · doi:10.3389/fphys.2025.1529113
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE271989_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1134252 and SRA study SRP519219. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.