← BioTransfer GEO Dataset Finder
GEO series

Drug-induced cis-regulatory elements in human hepatocytes affect molecular phenotypes associated with drug efficacy and adverse reactions

GSE272109 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/07/24 Platform GPL18573
Summary
We conducted a quantitative assessment of drug-inducible cis-regulatory elements (CREs) based on transcription initiation profiling of mRNAs and noncoding RNAs, including enhancer RNAs, by using CAGE (Cap Analysis of Gene Expression). Candidate CREs were identified in a hepatocellular carcinoma HepG2 cell line with stable expression of drug-responsive transcription factor pregnane X receptor (PXR) .
Published in
Drug-induced cis-regulatory elements in human hepatocytes affect molecular phenotypes associated with adverse reactions
Gotoh-Saito S, Wada R, Nishimura T et al. · Nature communications 2025 · PMID 40301309 · doi:10.1038/s41467-025-59132-3
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE272109_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1135139 and SRA study SRP519554. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.