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Characterization of Dipyridamole as a Novel Ferroptosis Inhibitor and its Therapeutic Potential in Acute Respiratory Distress Syndrome Management

GSE272163 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/12/18 Platform GPL24676
Summary
Ferroptosis in lung epithelium and endothelium contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), a critical and frequently fatal condition marked by acute inflammation and elevated pulmonary vascular permeability. Despite this, there are currently no FDA-approved therapeutics specifically targeting ferroptosis for ARDS management. In this investigation, we identified Dipyridamole (DIPY) as a potent ferroptosis inhibitor in pulmonary epithelial and endothelial cells via screening 259 FDA-approved drugs. The anti-ferroptotic and therapeutic efficacy of DIPY was validated in two ARDS mouse models (LPS-induced acute lung injury and CLP-induced sepsis) and human airway organoids (hAOs).
Published in
Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management
Chen X, Shen J, Jiang X et al. · Theranostics 2024 · PMID 39629132 · doi:10.7150/thno.102318
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Also filed as BioProject PRJNA1135240 and SRA study SRP519667. Searching any of these in the dataset finder brings you back here.

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