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Characteristics of a CCL21-gene modified dendritic cell vaccine utilized for a clinical trial in non-small cell lung cancer

GSE272174 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/11/14 Platform GPL24676
Summary
Samples are from a phase I clinical trial of a vaccine consisting of monocyte-derived DCs (moDCs) modified to express the chemokine CCL21 given in combination with pembrolizumab, conducted in patients with advanced non-small cell lung cancer. Single cell RNA sequencing of pre- and post-transduced vaccines was performed to characterize the cellular composition of these vaccines and assess the trascriptional impact of the transduction process. The same vaccine production procedure was also applied to blood obtained from healthy donors to investigate the effects of donor source on DC vaccine phenotype.
Published in
Characteristics of a CCL21 Gene-Modified Dendritic Cell Vaccine Utilized for a Clinical Trial in Non-Small Cell Lung Cancer
Oh MS, Dumitras C, Salehi-Rad R et al. · Molecular cancer therapeutics 2025 · PMID 39559833 · doi:10.1158/1535-7163.MCT-24-0435
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Direct links to NCBI, no account and no request form: the whole study as GSE272174_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1135255 and SRA study SRP519697. Searching any of these in the dataset finder brings you back here.

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