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Helicobacter pylori-induced PPFIA4 promotes gastritis and gastric bacterial colonization

GSE272270 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/11 Platform GPL24676
Summary
Bacterial-modulated gastric epithelial cells (GECs) play key roles in H. pylori-associated pathology. Here we demonstrate both pro-colonization and pro-inflammation roles of GEC-derived PPFIA4, originally expressed in nervous system, in H. pylori infection. PPFIA4 was elevated in gastric mucosa of H. pylori-infected patients and mice. PPFIA4 in GECs was synergistically induced by H. pylori and IL-33 in a cagA-dependent manner. Human gastric PPFIA4 correlated with H. pylori colonization and the severity of gastritis, and H. pylori colonization and inflammation were attenuated in Ppfia4-/- and Ppfia4ΔGEC mice.Overall, we propose a model in which PPFIA4 collectively ensures H. pylori persistence and promotes gastritis.
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Also filed as BioProject PRJNA1135990 and SRA study SRP520517. Searching any of these in the dataset finder brings you back here.

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