GEO series
Lipid overload-induced R Loops formed by m6A-modified circTACC3
GSE272486
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
16 samples
2025/12/04
GPL24676
Summary
To further elucidate the pathological characteristics of circTACC3-R loops in the HCC genome, circR loops were enriched by DRIP from lipid overload-induced HCC cells. Based on this premise, we devised an oligonucleotide probe specifically targeting the BSJ region of circTACC3, and used a ChIRP assay to selectively enrich the circR loops formed by endogenous circTACC3, named “DRIP-ChIRP”, by which specific enrichment of circTACC3 was detected within global circR loops and circTACC3-R loops
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Paper (PMID 41103024) ↗
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