GEO series
Therapeutic silencing Spp1 in cardiac macrophages suppresses atrial fibrillation
GSE272503
Mus musculus
Expression profiling by high throughput sequencing
14 samples
2024/09/12
GPL24247GPL34290
Summary
Atrial fibrillation (AFib) and the risk of its lethal complications are worsened by atrial fibrosis. A recent study implicates osteopontin (encoded by Spp1) secreted by atrial TREM2+ macrophages in this fibrosis. Here, we show that silencing Spp1 in TREM2+ cardiac macrophages using an antibody-siRNA conjugate (ARC) reduces atrial fibrosis and suppresses AFib, thus offering a new immunotherapy for this common arrhythmia.
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Paper (PMID 39149373) ↗
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