A novel association of EZH2 and E2F1 promotes breast cancer cell proliferation through chromatin remodeling [RNA-Seq]
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Breast cancerThis series is part of our curated briefing on it.
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Noncanonical association of EZH2 with E2F1 promotes tumor proliferation through chromatin remodelingExperimental & molecular medicine · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272538_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1137308 and SRA study SRP520756. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8404248 MDA-MB-231 Control shRNA replicate 1 [RNA-seq]
- GSM8404249 MDA-MB-231 Control shRNA replicate 2 [RNA-seq]
- GSM8404250 MDA-MB-231 shEZH2 replicate 1 [RNA-seq]
- GSM8404251 MDA-MB-231 shEZH2 replicate 2 [RNA-seq]
- GSM8404252 MDA-MB-231 shE2F1 replicate 1 [RNA-seq]
- GSM8404253 MDA-MB-231 shE2F1 replicate 2 [RNA-seq]
- GSM8404254 MDA-MB-231 DMSO rep1 [RNA-seq]
- GSM8404255 MDA-MB-231 GSK126 rep1 [RNA-seq]
- GSM8743113 MDA-MB-231, Control shRNA, replicate 1 [RNA-seq]
- GSM8743114 MDA-MB-231, Control shRNA, replicate 2 [RNA-seq]
- GSM8743115 MDA-MB-231, shEZH2, replicate 1 [RNA-seq]
- GSM8743116 MDA-MB-231, shEZH2, replicate 2 [RNA-seq]
- GSM8743117 MDA-MB-231, shE2F1, replicate 1 [RNA-seq]
- GSM8743118 MDA-MB-231, shE2F1, replicate 2 [RNA-seq]
- GSM8743119 MDA-MB-231, DMSO, replicate 1 [RNA-seq]
- GSM8743120 MDA-MB-231, DMSO, replicate 2 [RNA-seq]
- GSM8743121 MDA-MB-231, GSK126, replicate 1 [RNA-seq]
- GSM8743122 MDA-MB-231, GSK126, replicate 2 [RNA-seq]
- GSE104193 Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signalling and malignant features in vitro and in vivo 32 samples same disease briefing · shares breast
- GSE104675 Role for the Transcriptional Activator ZRF1 in Breast Cancer Progression and Endocrine Resistance 6 samples same disease briefing · shares breast
- GSE10886 A Supervised Risk Predictor of Breast Cancer Based on Biological Subtypes 226 samples same disease briefing · shares breast
- GSE11121 The humoral immune system has a key prognostic impact in node-negative breast cancer 200 samples same disease briefing · shares breast
- GSE10885 An integromic analysis reveals that metaplastic carcinomas are distinct from basal-like tumors. 244 samples same disease briefing
- GSE229736 Therapy Induced Senescence Promotes Immunogenicity in Acute Myeloid Leukemia through Reduced EZH2 Activity (RNA-seq AraC) 12 samples shares ezh2, promotes, rna-seq
- GSE314625 WSTF deficiency reprograms regulatory networks by linking locus‑specific chromatin remodeling to altered isoform expression and misdirected signaling [mRNA-seq] 18 samples shares remodeling, chromatin, rna-seq
- GSE237951 Inhibition of EZH2 restores normal expression of genes associated with cysteine metabolism and ferroptosis in hepatocellular carcinoma [RNA-seq] 8 samples shares ezh2, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.