Siglec-G suppresses CD8+ T cells responses through metabolic rewiring and can be targeted to enhance tumor immunotherapy

Direct links to NCBI, no account and no request form: the whole study as GSE272544_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1137322 and SRA study SRP520769. Searching any of these in the dataset finder brings you back here.

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• GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples
• GSE278990 Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity 73 samples
• GSE302792 SenCat: Cataloging human cell senescence through multiomic profiling of multiple senescent primary cell types 33 samples
• GSE304945 Tumor-borne ADAMTSL4 drives cancer cachexia via TGFβ signaling pathway 32 samples
• GSE322551 Engineered bacteria as exogenous organelle mimics restore PTEN and p53 tumor suppressor functions for cancer therapy 30 samples
• GSE327176 Single-cell transcriptomic profiling unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis 25 samples
• GSE285471 APOE genotype modifies the gene signature of microglial and astrocytic responses to aging 24 samples
• GSE269187 ZEB2 is a Master Switch Controlling the Tumor-Associated Macrophage Program [in vitro] 17 samples

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