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Autoimmune CD4 T cells maintain function and survive in chronic autoimmunity by restricting terminal differentiation

GSE272660 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/10/12 Platform GPL34475
Summary
The mechanisms behind survival of autoimmune CD4 T cells during chronic stimulation are unclear. Examining early time-points during T cell priming showed that activation of autoimmune CD4 T cells in the absence of infectious signals allowed maintenance of TCF1 expression, albeit at reduced levels. Tcf7 locus was epigenetically modified in circulating autoimmune CD4 T cells, suggesting a pre-programmed de novo methylation of the locus in early stages of autoimmune CD4 T cell differentiation which mirrored the epigenetic profile of recently recruited CD4 CD62L+ T cells in the tissue. Collectively, the data presented here show that the unique environment during autoimmune CD4 T cell priming allows T cells to finetune TCF1 expression to maintain long-term survival and function.
Published in
Autoimmune CD4(+) T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes
Aljobaily N, Allard D, Perkins B et al. · Immunity 2024 · PMID 39396521 · doi:10.1016/j.immuni.2024.09.016
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Also filed as BioProject PRJNA1137917 and SRA study SRP521005. Searching any of these in the dataset finder brings you back here.

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