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Caulerpin alleviates cyclophosphamide -induced ovarian dysfunction by modulating macrophage-associated granulosa cells senescence in breast cancer

GSE272762 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/07/27 Platform GPL23479
Summary
In this study, xenograft tumors of the breast cancer cell line MDA-MB-231 in female BALB/c nude mice model were established. It demonstrates that cyclophosphamide (CTX) alone caused a remarkable ovarian damage, including irregular estrous cycles, follicle loss and reduced expression in anti-Mullerian hormone (AMH) and follicle-stimulating hormone receptor (FSHR), while the ovarian toxicity can be largely reduced after caulerpin treatment in mice and in vitro.
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Also filed as BioProject PRJNA1138688 and SRA study SRP521353. Searching any of these in the dataset finder brings you back here.

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