Integration of transcriptomics, proteomics, phosphoproteomics analysis for characterization of pulmonary arterial hypertension in Chinese people
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 8 × PAH vs 8 × CONGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Comprehensive proteomic characterization of pulmonary arterial hypertension in Chinese peopleFrontiers in molecular biosciences · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272776_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1138715 and SRA study SRP521378. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 2 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8410664 PAH1 PAH
- GSM8410665 PAH2 PAH
- GSM8410666 PAH3 PAH
- GSM8410667 PAH4 PAH
- GSM8410668 PAH5 PAH
- GSM8410669 PAH6 PAH
- GSM8410670 PAH7 PAH
- GSM8410671 PAH8 PAH
- GSM8410672 CON1 CON
- GSM8410673 CON2 CON
- GSM8410674 CON3 CON
- GSM8410675 CON4 CON
- GSM8410676 CON5 CON
- GSM8410677 CON6 CON
- GSM8410678 CON7 CON
- GSM8410679 CON8 CON
- GSE254617 Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension. 148 samples shares hypertension, pulmonary, arterial
- GSE303084 Pressure Points: Endothelial Responses to Hemodynamic Stress in Health and Pulmonary Arterial Hypertension 72 samples shares hypertension, pulmonary, arterial
- GSE244781 Molecular changes implicate angiogenesis and arterial remodeling in systemic sclerosis-associated and idiopathic pulmonary hypertension 33 samples shares hypertension, pulmonary, arterial
- GSE263226 Unravelling AURKB as a potential therapeutic target in pulmonary arterial hypertension using integrated transcriptomic analysis and pre-clinical studies 31 samples shares hypertension, pulmonary, arterial
- GSE277556 Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights from Comprehensive Multicenter Preclinical Studies 20 samples shares hypertension, pulmonary, arterial
- GSE21284 A critical role of microRNAs in human pulmonary arterial hypertension. miR-204: a novel therapeutic target 8 samples shares hypertension, pulmonary, arterial
- GSE325715 Gene expression in patients with pulmonary hypertension due to valve heart disease 146 samples shares hypertension, pulmonary
- GSE249697 Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension governs right ventricle remodeling and recovery 135 samples shares hypertension, pulmonary
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.