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Multi-omics datasets for finer-scale dissection of chromatin architecture alterations in radiation induced malignant transformation of bronchial epithelial cells [CTCF CUT&Tag]

GSE272819 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 5 samples Submitted 2024/07/26 Platform GPL24676
Summary
we generated CUT&Tag, ATAC-seq, RNA-seq, high-resolution Hi-C and Micro-C datasets for finer-scale dissection of chromatin architecture alterations in radiation induced malignant transformation of bronchial epithelial cells.
Published in
TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesis
Liu Q, Jiang S, Xu X et al. · Nature communications 2025 · PMID 41028778 · doi:10.1038/s41467-025-63754-y
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Direct links to NCBI, no account and no request form: the whole study as GSE272819_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1138790 and SRA study SRP521455. Searching any of these in the dataset finder brings you back here.

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